Hydrogels Composed of Cyclodextrin Inclusion Complexes with PLGA-PEG-PLGA Triblock Copolymers as Drug Delivery Systems

被引：0
|
作者：
Elham Khodaverdi
Farnaz Sadat Mirzazadeh Tekie
Farzin Hadizadeh
Haydar Esmaeel
Seyed Ahmad Mohajeri
Sayyed A. Sajadi Tabassi
Gholamhossein Zohuri
机构：
[1] Mashhad University of Medical Sciences,Targeted Drug Delivery Research Center, School of Pharmacy
[2] Tehran University of Medical Sciences,Nanotechnology Research Centre, School of Pharmacy
[3] Mashhad University of Medical Sciences,Biotechnology Research Center, School of Pharmacy
[4] Mashhad University of Medical Sciences,Student Research Committee, School of Pharmacy
[5] Mashhad University of Medical Sciences,Pharmacological Research Center of Medicinal Plants, School of Medicine
[6] Ferdowsi University,Department of Chemistry, Faculty of Science
来源：
AAPS PharmSciTech | 2014年 / 15卷
关键词：
α-Cyclodextrin; controlled release; naltrexone hydrochloride; PLGA-PEG-PLGA; supramolecular hydrogel; vitamin B12;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Although conventional pharmaceuticals have many drug dosage forms on the market, the development of new therapeutic molecules and the low efficacy of instant release formulations for the treatment of some chronic diseases and specific conditions encourage scientists to invent different delivery systems. To this purpose, a supramolecular hydrogel consisting of the tri-block copolymer PLGA-PEG-PLGA and α-cyclodextrin was fabricated for the first time and characterised in terms of rheological, morphological, and structural properties. Naltrexone hydrochloride and vitamin B12 were loaded, and their release profiles were determined.
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页码：177 / 188
页数：11
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