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Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Royal Brompton & Harefield NHS Trust, Dept Cardiol, London SW3 6NP, England Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Royal Brompton & Harefield NHS Trust, Dept Cardiol, London SW3 6NP, England