Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1∗13:02-negative individuals of a Japanese population

被引：9

作者：

Shimada-Sugimoto M. ^{[1
]}

Otowa T. ^{[1
]}

Miyagawa T. ^{[3
]}

Khor S.-S. ^{[5
]}

Omae Y. ^{[6
]}

Toyo-Oka L. ^{[7
]}

Sugaya N. ^{[8
]}

Kawamura Y. ^{[9
]}

Umekage T. ^{[10
]}

Miyashita A. ^{[11
]}

Kuwano R. ^{[12
]}

Kaiya H. ^{[2
]}

Kasai K. ^{[4
]}

Tanii H. ^{[5
]}

Okazaki Y. ^{[6
]}

Tokunaga K. ^{[7
]}

Sasaki T. ^{[8
]}

机构：

[1] Department of Human Genetics, School of Medicine, University of Tokyo, Tokyo

[2] School of Clinical Psychology, Teikyo Heisei University Major of Professional Clinical Psychology, Tokyo

[3] Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo

[4] Department of Epidemiology and Public Health, School of Medicine, Yokohama City University, Kanagawa

[5] Department of Psychiatry, Shonan Kamakura General Hospital, Kanagawa

[6] Division for Environment, Health and Safety, University of Tokyo, Tokyo

[7] Department of Molecular Genetics, Center for Bioresources, Niigata University, Niigata

[8] Panic Disorder Research Center, Warakukai Med. Corp, Tokyo

[9] Department of Neuropsychiatry, School of Medicine, University of Tokyo, Tokyo

[10] Department of Psychiatry, Institute of Medical Life Science, Mie University, Mie

[11] Tokyo Metropolitan Matsuzawa Hospital, Tokyo

[12] Department of Physical and Health Education, School of Education, University of Tokyo, Tokyo

来源：

Human Genome Variation | / 3卷 / 1期

基金：

日本学术振兴会;

关键词：

D O I：

10.1038/hgv.2016.1

中图分类号：

学科分类号：

摘要：

We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB1∗13:02, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB1∗13:02 (rs4759997; P=5.02×10 â'6, odds ratio=1.50) but not in those with the HLA allele. TMEM132D might have a role in the development of PD in subjects without HLA-DRB1∗13:02. © 2016 The Japan Society of Human Genetics.

引用

共 3 条

[1] Immune-related pathways including HLA-DRB1*13:02 are associated with panic disorder
Shimada-Sugimoto, Mihoko
Otowa, Takeshi
Miyagawa, Taku
Khor, Seik-Soon
Kashiwase, Koichi
Sugaya, Nagisa
Kawamura, Yoshiya
Umekage, Tadashi
Kojima, Hiroto
Saji, Hiroh
Miyashita, Akinori
Kuwano, Ryozo
Kaiya, Hisanobu
Kasai, Kiyoto
Tanii, Hisashi
Okazaki, Yuji
Tokunaga, Katsushi
Sasaki, Tsukasa
BRAIN BEHAVIOR AND IMMUNITY, 2015, 46 : 96 - 103
[2] Protective Association of HLA-DRB1*13:02 Against MPO-ANCA Positive ANCA-Associated Vasculitis in a Japanese Population.
Tsuchiya, Naoyuki
Hasebe, Narumi
Sada, Ken-ei
Kobayashi, Shigeto
Yamada, Hidehiro
Furukawa, Hiroshi
Yamagata, Kunihiro
Sumida, Takayuki
Miyasaka, Nobuyuki
Matsuo, Seiichi
Tohma, Shigeto
Ozaki, Shoichi
Hashimoto, Hiroshi
Makino, Hirofumi
Harigai, Masayoshi
Kawasaki, Aya
ARTHRITIS & RHEUMATOLOGY, 2014, 66 : S36 - S36
[3] Protective Role of HLA-DRB1*13:02 against Microscopic Polyangiitis and MPO-ANCA-Positive Vasculitides in a Japanese Population: A Case-Control Study
Kawasaki, Aya
Hasebe, Narumi
Hidaka, Misaki
Hirano, Fumio
Sada, Ken-ei
Kobayashi, Shigeto
Yamada, Hidehiro
Furukawa, Hiroshi
Yamagata, Kunihiro
Sumida, Takayuki
Miyasaka, Nobuyuki
Tohma, Shigeto
Ozaki, Shoichi
Matsuo, Seiichi
Hashimoto, Hiroshi
Makino, Hirofumi
Arimura, Yoshihiro
Harigai, Masayoshi
Tsuchiya, Naoyuki
PLOS ONE, 2016, 11 (05):

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