Deep structural brain lesions associated with consciousness impairment early after hemorrhagic stroke

被引:0
|
作者
Benjamin Rohaut
Kevin W. Doyle
Alexandra S. Reynolds
Kay Igwe
Caroline Couch
Adu Matory
Batool Rizvi
David Roh
Angela Velazquez
Murad Megjhani
Soojin Park
Sachin Agarwal
Christine M. Mauro
Gen Li
Andrey Eliseyev
Vincent Perlbarg
Sander Connolly
Adam M. Brickman
Jan Claassen
机构
[1] Columbia University,Department of Neurology, Critical Care Neurology
[2] Columbia University,Department of Neurology, The Taub Institute, Gertrude H. Sergievsky Center
[3] Columbia University,Mailman School of Public Health, Department of Biostatistics
[4] iCONICS,Bioinformatics and Biostatistics Core Facility
[5] IHU-A-ICM,Department of Neurosurgery
[6] Institut du Cerveau et de la Moelle épinière,undefined
[7] Columbia University,undefined
来源
关键词
D O I
暂无
中图分类号
学科分类号
摘要
The purpose of this study was to determine the significance of deep structural lesions for impairment of consciousness following hemorrhagic stroke and recovery at ICU discharge. Our study focused on deep lesions that previously were implicated in studies of disorders of consciousness. We analyzed MRI measures obtained within the first week of the bleed and command following throughout the ICU stay. A machine learning approach was applied to identify MRI findings that best predicted the level consciousness. From 158 intracerebral hemorrhage patients that underwent MRI, one third was unconscious at the time of MRI and half of these patients recovered consciousness by ICU discharge. Deep structural lesions predicted both, impairment and recovery of consciousness, together with established measures of mass effect. Lesions in the midbrain peduncle and pontine tegmentum alongside the caudate nucleus were implicated as critical structures. Unconscious patients predicted to recover consciousness by ICU discharge had better long-term functional outcomes than those predicted to remain unconscious.
引用
收藏
相关论文
共 50 条
  • [1] Deep structural brain lesions associated with consciousness impairment early after hemorrhagic stroke
    Rohaut, Benjamin
    Doyle, Kevin W.
    Reynolds, Alexandra S.
    Igwe, Kay
    Couch, Caroline
    Matory, Adu
    Rizvi, Batool
    Roh, David
    Velazquez, Angela
    Megjhani, Murad
    Park, Soojin
    Agarwal, Sachin
    Mauro, Christine M.
    Li, Gen
    Eliseyev, Andrey
    Perlbarg, Vincent
    Connolly, Sander
    Brickman, Adam M.
    Claassen, Jan
    [J]. SCIENTIFIC REPORTS, 2019, 9 (1)
  • [2] Disruption of brain connectivity in acute stroke patients with early impairment in consciousness
    Tsai, Yuan-Hsiung
    Yuan, Rui
    Huang, Yen-Chu
    Yeh, Mei-Yu
    Lin, Ching-Po
    Biswal, Bharat B.
    [J]. FRONTIERS IN PSYCHOLOGY, 2014, 4
  • [3] Early impairment in consciousness predicts mortality after hemispheric ischemic stroke
    Cucchiara, BL
    Kasner, SE
    Wolk, DA
    Lyden, PD
    Knappertz, VA
    Ashwood, T
    Odergren, T
    Nordlund, A
    [J]. CRITICAL CARE MEDICINE, 2004, 32 (01) : 241 - 245
  • [4] Characteristic of Cognitive Impairment After Hemorrhagic Stroke
    Sibarani, Rita Magda Helena
    [J]. CEREBROVASCULAR DISEASES, 2014, 38 : 71 - 72
  • [5] Neuropsychological impairment after hemorrhagic stroke in basal ganglia
    Su, Chwen-Yng
    Chen, Hui-Mei
    Kwan, Aij-Lie
    Lin, Yueh-Hsieh
    Guo, Nai-Wen
    [J]. ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 2007, 22 (04) : 465 - 474
  • [6] Diagnosis of Hemorrhagic Stroke in an Exhumed Brain After Three Years of Burial in a Deep Grave
    Omalu, Bennet
    Hammers, Jennifer
    Luckasevic, Todd
    [J]. JOURNAL OF FORENSIC SCIENCES, 2012, 57 (06) : 1665 - 1668
  • [7] Early seizures after hemorrhagic and ischemic stroke
    Mateiescu, E. C.
    Popoviciu, D.
    [J]. EUROPEAN JOURNAL OF NEUROLOGY, 2006, 13 : 174 - 175
  • [8] Early rehabilitation after intracerebral hemorrhagic stroke
    Liu N
    Cadilhac DA
    Andrew NE
    [J]. 中华物理医学与康复杂志, 2015, (01) : 23 - 23
  • [9] Cognition Is Associated with Brain Volumes Early after Ischaemic Stroke
    Werden, E.
    Cumming, T.
    Li, Q.
    Brodtmann, A.
    [J]. CEREBROVASCULAR DISEASES, 2016, 42 : 13 - 13
  • [10] Factors Associated With Anxiety After Hemorrhagic Stroke
    Olivera, Anlys
    Ecker, Sarah
    Lord, Aaron
    Gurin, Lindsey
    Ishida, Koto
    Melmed, Kara
    Torres, Jose
    Zhang, Cen
    Frontera, Jennifer
    Lewis, Ariane
    [J]. JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 2024, 36 (01) : 36 - 44