Synthesis of trifluoromethyl derivatives of pyrazolidine- and 2-pyrazoline-1-carboxamides and pyrazolidine- and 1-pyrazoline-carbothioamides

被引：0
|
作者：
Sanin A.V.
Nenaidenko V.G.
Kuz'min V.S.
Balenkova E.S.
机构：
来源：
Chemistry of Heterocyclic Compounds | 1998年 / 34卷 / 5期
关键词：
Organic Chemistry; Basic Medium; Trifluoromethyl; Ethoxy; Addition Product;
D O I：
10.1007/BF02290939
中图分类号：
学科分类号：
摘要：
The reactions of enones containing trifluoromethyl groups with semicarbazide in basic media proceed unequivocally to give pyrazolidine-1-carboxamides. The direction of the reactions of these enones with thiosemicarbazide depends on their structure; the reaction products are pyrazolidine- and 2-pyrazoline-1-carbothioamides. An enone containing a CF3 group and an ethoxy group capable of replacement reacts with semicarbazide to give 2-pyrazoline-1-carboxamide and with thiosemicarbazide to give the double addition product, 5-(1-thiosemicarbazido)-2-pyrazoline-1-carbothiamide. ©1998 Plenum Publishing Corporation.
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页码：558 / 567
页数：9
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