Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy

被引：0
|
作者：
Monica Xiong
Chao Wang
Maud Gratuze
Fareeha Saadi
Xin Bao
Megan E. Bosch
Choonghee Lee
Hong Jiang
Javier Remolina Serrano
Ernesto R. Gonzales
Michal Kipnis
David M. Holtzman
机构：
[1] Knight Alzheimer’s Disease Research Center,Department of Neurology, Hope Center for Neurological Disorders
[2] Washington University School of Medicine,Division of Biology and Biomedical Sciences (DBBS)
[3] Washington University School of Medicine,Institute for Brain Science and Disease
[4] Present Address: Genentech,Present address: Institute of Neurophysiopathology (INP UMR7051), CNRS
[5] Chongqing Medical University,undefined
[6] Aix-Marseille Université,undefined
来源：
Molecular Neurodegeneration | / 18卷
关键词：
APOE; Cerebral amyloid angiopathy; Cerebrovasculature; Astrocyte; Amyloid-β;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 25 条
  • [1] Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
    Xiong, Monica
    Wang, Chao
    Gratuze, Maud
    Saadi, Fareeha
    Bao, Xin
    Bosch, Megan E.
    Lee, Choonghee
    Jiang, Hong
    Serrano, Javier Remolina
    Gonzales, Ernesto R.
    Kipnis, Michal
    Holtzman, David M.
    [J]. MOLECULAR NEURODEGENERATION, 2023, 18 (01)
  • [2] Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer's disease
    Shinohara, Mitsuru
    Murray, Melissa E.
    Frank, Ryan D.
    Shinohara, Motoko
    DeTure, Michael
    Yamazaki, Yu
    Tachibana, Masaya
    Atagi, Yuka
    Davis, Mary D.
    Liu, Chia-Chen
    Zhao, Na
    Painter, Meghan M.
    Petersen, Ronald C.
    Fryer, John D.
    Crook, Julia E.
    Dickson, Dennis W.
    Bu, Guojun
    Kanekiyo, Takahisa
    [J]. ACTA NEUROPATHOLOGICA, 2016, 132 (02) : 225 - 234
  • [3] Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease
    Mitsuru Shinohara
    Melissa E. Murray
    Ryan D. Frank
    Motoko Shinohara
    Michael DeTure
    Yu Yamazaki
    Masaya Tachibana
    Yuka Atagi
    Mary D. Davis
    Chia-Chen Liu
    Na Zhao
    Meghan M. Painter
    Ronald C. Petersen
    John D. Fryer
    Julia E. Crook
    Dennis W. Dickson
    Guojun Bu
    Takahisa Kanekiyo
    [J]. Acta Neuropathologica, 2016, 132 : 225 - 234
  • [4] APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function
    Xiong, Monica
    Jiang, Hong
    Serrano, Javier Remolina
    Gonzales, Ernesto R.
    Wang, Chao
    Gratuze, Maud
    Hoyle, Rosa
    Bien-Ly, Nga
    Silverman, Adam P.
    Sullivan, Patrick M.
    Watts, Ryan J.
    Ulrich, Jason D.
    Zipfel, Gregory J.
    Holtzman, David M.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2021, 13 (581)
  • [5] Cerebral Amyloid Angiopathy Is Associated with APOE4 and CERAD Plaque Staging, but Not Clinical Dementia in the Oldest-Old
    Berlau, Daniel
    Corrada, Maria
    Peltz, Carrie
    Balasubramanian, Archana
    Kawas, Claudia
    [J]. NEUROLOGY, 2011, 76 (09) : A118 - A118
  • [6] Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer's tau pathology
    Huang, Shichao
    Zhang, Zhen
    Cao, Junwei
    Yu, Yongchun
    Pei, Gang
    [J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2022, 7 (01)
  • [7] Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer’s tau pathology
    Shichao Huang
    Zhen Zhang
    Junwei Cao
    Yongchun Yu
    Gang Pei
    [J]. Signal Transduction and Targeted Therapy, 7
  • [8] APOE-ε2 and APOE-ε4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature
    Nelson, Peter T.
    Pious, Nina M.
    Jicha, Gregory A.
    Wilcock, Donna M.
    Fardo, David W.
    Estus, Steven
    Rebeck, G. William
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2013, 72 (07): : 708 - 715
  • [9] Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice
    Thomas, Riya
    Zuchowska, Paulina
    Morris, Alan W. J.
    Marottoli, Felecia M.
    Sunny, Sangeeta
    Deaton, Ryan
    Gann, Peter H.
    Tai, Leon M.
    [J]. ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2016, 4 : 111
  • [10] Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice
    Riya Thomas
    Paulina Zuchowska
    Alan W. J. Morris
    Felecia M. Marottoli
    Sangeeta Sunny
    Ryan Deaton
    Peter H. Gann
    Leon M. Tai
    [J]. Acta Neuropathologica Communications, 4
123