Serum steroids in relation to prostate cancer risk in a case-control study (Greece)

被引：0
|
作者：
Lisa B. Signorello
Anastasia Tzonou
Christos S. Mantzoros
Loren Lipworth
Pagona Lagiou
Chung-cheng Hsieh
Meir Stampfer
Dimitrios Trichopoulos
机构：
[1] Harvard School of Public Health,Department of Epidemiology and Harvard Center for Cancer Prevention
[2] University of Athens Medical School,Department of Hygiene and Epidemiology
[3] Harvard Medical School,Division of Endocrinology, Beth Israel Deaconess Medical Center
[4] National School of Public Health,Department of Nutrition and Biochemistry
[5] University of Massachusetts Medical Center,Cancer Center
来源：
Cancer Causes & Control | 1997年 / 8卷
关键词：
Dihydrotestosterone; estradiol; Greece; men; prostate cancer; sex hormone-binding globulin; testosterone;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Blood samples were collected from 52 incident cases of histologicallyconfirmed prostate cancer and 52 age- and town of residence-matched healthycontrols in Athens, Greece. Samples were analyzed blindly in Boston,Massachusetts (USA) for testosterone (T), estradiol (E2), sex hormone-bindingglobulin (SHBG), and dihydrotestosterone (DHT). The data were modeled usingmultiple logistic regression with adjustment for age, height, body mass index(wt/ht2), years of schooling, and mutually among hormones. DHT was associatedinversely, significantly, and strongly with the risk of prostate cancer,whereas T was associated marginally positively, and E2 was associatednonsignificantly inversely with the disease. No association was observed inthis study with respect to SHBG.
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页码：632 / 636
页数：4
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