Epigenetic System: A Pathway to Malignancies and a Therapeutic Target

被引：0
|
作者：
Mitsuyoshi Nakao
Takeshi Minami
Yasuaki Ueda
Yasuo Sakamoto
Takaya Ichimura
机构：
[1] Kumamoto University,Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics
来源：
International Journal of Hematology | 2004年 / 80卷
关键词：
Epigenetics; Chromatin; Histone; Cancer; Therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cancer cells possess both genetic and epigenetic alterations that dysregulate essential cellular processes, leading to disordered cell proliferation and differentiation. Oncogenes and tumor suppressor genes have been found to be activated and inactivated, respectively, in malignant cells. Epigenetic regulation of the genome is mediated by interactions between DNA methylation, chromatin, and modifications of histones and various transcriptional regulators. Recent studies have shown that some components of the epigenetic system as well as epigenetically mutated genes are diagnostic and therapeutic targets in cancer. We discuss the molecular basis of the epigenetic mechanism in association with the development of cancer.
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页码：103 / 107
页数：4
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