Antisense ATM gene therapy: a strategy to increase the radiosensitivity of human tumors

被引：0
|
作者：
C Guha
U Guha
S Tribius
A Alfieri
D Casper
P Chakravarty
W Mellado
T K Pandita
B Vikram
机构：
[1] Montefiore,Department of Radiation Oncology of the Albert Einstein College of Medicine
[2] Beth Israel Medical Centers,undefined
[3] Department of Neurological Surgery of the Albert Einstein College of Medicine,undefined
[4] Center for Radiological Research,undefined
[5] Columbia University,undefined
来源：
Gene Therapy | 2000年 / 7卷
关键词：
antisense gene therapy; ATM; radiation therapy; glioblastoma multiforme;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Atm, the gene mutated in ataxia-telangiectasia (AT) patients, is an essential component of the signal transduction pathway that responds to DNA damage due to ionizing radiation (IR). We attenuated ATM protein expression in human glioblastoma cells by expressing antisense RNA to a functional domain of the atm gene. While ATM expression decreased, constitutive expression of p53 and p21 increased. Irradiated ATM-attenuated cells failed to induce p53, demonstrated radioresistant DNA synthesis, and increased radiosensitivity. Antisense-ATM gene therapy in conjunction with radiation therapy may provide a novel strategy for the treatment of cancer.
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页码：852 / 858
页数：6
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