The value of the chloride:sodium ratio in differentiating the aetiology of metabolic acidosis

被引：0
|
作者：
A. Durward
S. Skellett
A. Mayer
D. Taylor
S. Tibby
I. Murdoch
机构：
[1] Paediatric Intensive Care Unit,
[2] 9th Floor (Guy's Tower),undefined
[3] Guy's Hospital,undefined
[4] St Thomas Street,undefined
[5] London,undefined
[6] SE1 9RT,undefined
[7] UK,undefined
来源：
Intensive Care Medicine | 2001年 / 27卷
关键词：
Chloride:sodium ratio Lactate Hyperchloraemic metabolic acidosis Paediatrics;
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学科分类号：
摘要：
Objective: Stewart's physicochemical approach to acid-base balance defines the aetiology of a metabolic acidosis by quantifying anions of tissue acids (TA), which consist of unmeasured anions (UMA) and/or lactate. We hypothesised that an increase in TA during metabolic acidosis would lead to a compensatory fall in the plasma chloride (Cl) relative to sodium (Cl:Na ratio) in order to preserve electro-neutrality. Thus, the Cl:Na ratio could be used as a simple alternative to the anion gap in identifying raised TA.
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页码：828 / 835
页数：7
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