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Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1

被引：0
|
作者：
Alessandro Vezzoli
Nicolas Bonadies
Mark D Allen
Stefan M V Freund
Clara M Santiveri
Brynn T Kvinlaug
Brian J P Huntly
Berthold Göttgens
Mark Bycroft
机构：
[1] MRC Centre for Protein Engineering,Department of Haematology
[2] Cambridge Institute for Medical Research,undefined
[3] University of Cambridge,undefined
[4] Medical Research Council Laboratory of Molecular Biology,undefined
来源：
Nature Structural & Molecular Biology | 2010年 / 17卷
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摘要：
The PWWP domain has been identified in a number of nuclear proteins that interact with histones including BRPF1. Structural and functional analysis of this domain from BRPF1 now argue that it specifically recognizes methylated histone H3 Lys36, identifying this widely conserved domain as a reader of this mark.
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页码：617 / 619
页数：2
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