Decreased interhemispheric functional connectivity in subtypes of Parkinson’s disease

被引:0
|
作者
Xiaofei Hu
Jiuquan Zhang
Xiaomei Jiang
Chaoyang Zhou
Luqing Wei
Xuntao Yin
Ya Wu
Jing Li
Yanling Zhang
Jian Wang
机构
[1] Third Military Medical University,Department of Radiology, Southwest Hospital
[2] Chengdu Military Region,Department of Centre for Disease Prevention and Control
[3] Third Military Medical University,Department of Neurology, Southwest Hospital
来源
Journal of Neurology | 2015年 / 262卷
关键词
Parkinson’s disease; Subtypes; Functional MRI; Voxel-mirrored homotopic connectivity;
D O I
暂无
中图分类号
学科分类号
摘要
Parkinson’s disease (PD) can be classified into tremor-dominant (TD) subtype and akinetic-rigid (AR) subtype, which exhibit different clinical courses and prognoses. However, the neural mechanisms underlying different subtypes of PD are not well understood. Using voxel-mirrored homotopic connectivity (VMHC), we examined the homotopic resting-state functional connectivity patterns in akinetic-rigid PD (AR-PD) and tremor-dominant PD (TD-PD) to study the neural basis for these disparate manifestations of PD. Twenty-one TD-PD patients, 29 AR-PD patients and 26 normal control subjects participated in this study. Resting-state fMRI data were analyzed using VMHC. Correlations between VMHC values and each clinical characteristic were also calculated. Compared with normal control subjects and subjects with AR-PD, subjects with TD-PD exhibited significantly lower VMHC values in the posterior lobe of the cerebellum. Moreover, tremor scores and VMHC values for the cerebellum were found to be significantly negatively correlated in TD-PD patients. By contrast, subjects with AR-PD exhibited lower VMHC values in the precentral gyrus compared with normal control subjects. These findings suggest that functional coordination between homotopic brain regions is impaired in AR-PD and TD-PD patients. This study provides evidence of both cerebellum-related connectivity deficits in TD-PD. The finding that VMHC values and tremor scores were significantly correlated suggests that VMHC measurements may be of potential clinical relevance in TD-PD.
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页码:760 / 767
页数:7
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