MeCP2: Making sense of missense in Rett syndrome

被引:0
|
作者
Abhishek Banerjee
Esmeralda Romero-Lorenzo
Mriganka Sur
机构
[1] The Picower Institute for Learning and Memory,Department of Brain and Cognitive Sciences
[2] Massachusetts Institute of Technology,undefined
来源
Cell Research | 2013年 / 23卷
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摘要
Fine scale genomic regulation is critical for maintaining genomic integrity and is often disrupted in neurodevelopmental disorders. An intriguing new study reveals the intricate biochemical complexity of de novo post-translational modifications of MeCP2, including activity-dependent protein-protein interactions that 'bridge' the nuclear receptor co-repressor (NCoR) complex to chromatin and lead to alterations in gene expression that characterize Rett syndrome.
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页码:1244 / 1246
页数:2
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