Synthesis and NMR elucidation of novel pentacyclo-undecane diamine ligands

被引：0
|
作者：
Oluseye K. Onajole
Patrick Govender
Thavendran Govender
Glenn E. M. Maguire
Hendrik G. Kruger
机构：
[1] University of KwaZulu-Natal,School of Chemistry
[2] University of KwaZulu-Natal,School of Biochemistry, Genetics and Microbiology
[3] University of KwaZulu-Natal,School of Pharmacy and Pharmacology
来源：
Structural Chemistry | 2009年 / 20卷
关键词：
2D NMR; Pentacyclo-undecane diamine; Ligands;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The synthesis and NMR elucidation of eight novel pentacyclo-undecane (PCU) diamine compounds are reported. These ligands are potential anti-inflammatory agents to be used against rheumatoid arthritis (RA). One-dimensional NMR techniques (1H and 13C spectra) show major overlapping of methine resonances of the “cage” (PCU) thereby making it extremely difficult to assign all NMR signals. This overlapping occurs as a result of the substitutions made at the quaternary carbons (C-8/C-11) of the cage. Two-dimensional NMR techniques proved to be a useful tool in overcoming this problem.
引用
收藏
页码：1067 / 1076
页数：9
相关论文
共 50 条
  • [1] Synthesis and NMR elucidation of novel pentacyclo-undecane diamine ligands
    Onajole, Oluseye K.
    Govender, Patrick
    Govender, Thavendran
    Maguire, Glenn E. M.
    Kruger, Hendrik G.
    [J]. STRUCTURAL CHEMISTRY, 2009, 20 (06) : 1067 - 1076
  • [2] Synthesis and NMR elucidation of pentacyclo-undecane diamine derivatives as potential anti-tuberculosis drugs
    Govender, Thavendran
    Kruger, Hendrik G.
    Makatini, Maya
    Onajole, Oluseye K.
    [J]. STRUCTURAL CHEMISTRY, 2008, 19 (05) : 719 - 726
  • [3] Synthesis and NMR elucidation of pentacyclo-undecane diamine derivatives as potential anti-tuberculosis drugs
    Thavendran Govender
    Hendrik G. Kruger
    Maya Makatini
    Oluseye K. Onajole
    [J]. Structural Chemistry, 2008, 19
  • [4] NMR elucidation of a novel (S)-pentacyclo-undecane bis-(4-phenyloxazoline) ligand and related derivatives
    Boyle, Grant A.
    Govender, Thavendran
    Kruger, Hendrik G.
    Maguire, Glenn E. M.
    Naicker, Tricia
    [J]. MAGNETIC RESONANCE IN CHEMISTRY, 2008, 46 (12) : 1089 - 1095
  • [5] Synthesis of chiral pentacyclo-undecane ligands and their use in the enantioselective alkylation of benzaldehyde with diethylzinc
    Boyle, GA
    Govender, T
    Kruger, HG
    Maguire, GEM
    [J]. TETRAHEDRON-ASYMMETRY, 2004, 15 (17) : 2661 - 2666
  • [6] Synthesis of chiral pentacyclo-undecane macrocycles and their use in enantioselective Michael addition reactions
    Boyle, GA
    Govender, T
    Kruger, HG
    Maguire, GEM
    [J]. TETRAHEDRON-ASYMMETRY, 2004, 15 (23) : 3775 - 3781
  • [7] Theoretical study on the formation of a pentacyclo-undecane cage lactam
    Singh, Thishana
    Kruger, Hendrik G.
    Bisetty, Krishna
    Power, Trevor D.
    [J]. COMPUTATIONAL AND THEORETICAL CHEMISTRY, 2012, 986 : 63 - 70
  • [8] A molecular dynamics study of the pentacyclo-undecane cage amino acid tripeptide
    Bisetty, Krishna
    Corcho, Francesc J.
    Canto, Josep
    Kruger, Hendrik G.
    Perez, Juan J.
    [J]. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 2006, 770 (1-3): : 221 - 228
  • [9] Pentacyclo-undecane derived cyclic tetra-amines: Synthesis and evaluation as potent anti-tuberculosis agents
    Onajole, Oluseye K.
    Govender, Karnishree
    Govender, Patrick
    van Helden, Paul D.
    Kruger, Hendrik G.
    Maguire, Glenn E. M.
    Muthusamy, Karen
    Pillay, Manormoney
    Wiid, Ian
    Govender, Thavendran
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (11) : 4297 - 4305
  • [10] A theoretical study of pentacyclo-undecane cage peptides of the type (Ac-X-Y-NHMe)
    Bisetty, K
    Corcho, FJ
    Canto, J
    Kruger, HG
    Perez, JJ
    [J]. JOURNAL OF PEPTIDE SCIENCE, 2006, 12 (02) : 92 - 105
12345