Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies

被引：0

作者：

Susan Service

Joseph DeYoung

Maria Karayiorgou

J Louw Roos

Herman Pretorious

Gabriel Bedoya

Jorge Ospina

Andres Ruiz-Linares

António Macedo

Joana Almeida Palha

Peter Heutink

Yurii Aulchenko

Ben Oostra

Cornelia van Duijn

Marjo-Riitta Jarvelin

Teppo Varilo

Lynette Peddle

Proton Rahman

Giovanna Piras

Maria Monne

Sarah Murray

Luana Galver

Leena Peltonen

Chiara Sabatti

Andrew Collins

Nelson Freimer

机构：

[1] Center for Neurobehavioral Genetics,Department of Psychiatry & Weskoppies Hospital

[2] University of California,Department of Psychiatry

[3] Southern California Genotyping Consortium,Department of Biology (Wolfson House)

[4] University of California,Department of Human Genetics

[5] Rockefeller University,Departments of Epidemiology & Biostatistics and Clinical Genetics

[6] University of Pretoria,Department of Public Health Science and General Practice

[7] Laboratory of Molecular Genetics,Department of Epidemiology and Public Health

[8] University of Antioquia,Department of Medical Genetics

[9] University of Antioquia,Department of Molecular Medicine

[10] The Galton Laboratory,Division of Haematology

[11] University College London,Department of Human Genetics

[12] Institute of Medical Psychology,Department of Statistics

[13] Faculty of Medicine,Human Genetics Research Division

[14] University of Coimbra,Department of Psychiatry

[15] Life and Health Sciences Research Institute (ICVS),undefined

[16] School of Health Sciences,undefined

[17] University of Minho,undefined

[18] Section of Medical Genomics,undefined

[19] Vrije University and Vrije University Medical Center,undefined

[20] Center for Neurogenomics and Cognitive Research,undefined

[21] Vrije University and Vrije University Medical Center,undefined

[22] Genetic Epidemiology Unit,undefined

[23] Erasmus Medical Center,undefined

[24] University of Oulu,undefined

[25] Imperial College London,undefined

[26] University of Helsinki,undefined

[27] National Public Health Institute,undefined

[28] Biomedicum Helsinki,undefined

[29] Newfound Genomics,undefined

[30] Memorial University of Newfoundland,undefined

[31] 'San Francesco' Hospital,undefined

[32] Illumina,undefined

[33] Inc.,undefined

[34] 9885 Towne Centre Dr.,undefined

[35] University of California,undefined

[36] University of California,undefined

[37] University of Southampton,undefined

[38] Southampton General Hospital,undefined

[39] The Jane and Terry Semel Institute for Neuroscience and Human Behavior,undefined

[40] University of California,undefined

[41] University of California,undefined

来源：

Nature Genetics | 2006年 / 38卷

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摘要：

The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22. Most isolates show substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (termed 'holes'). Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping.

引用

页码：556 / 560

页数：4

共 50 条

[1] Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies
Service, S
DeYoung, J
Karayiorgou, M
Roos, JL
Pretorious, H
Bedoya, G
Ospina, J
Ruiz-Linares, A
Macedo, A
Palha, JA
Heutink, P
Aulchenko, Y
Oostra, B
van Duijn, C
Jarvelin, MR
Varilo, T
Peddle, L
Rahman, P
Piras, G
Monne, M
Murray, S
Galver, L
Peltonen, L
Sabatti, C
Collins, A
Freimer, N
[J]. NATURE GENETICS, 2006, 38 (05) : 556 - 560
[2] Genome-wide distribution of linkage disequilibrium in the Samoan population.
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