Cognitive impairment experienced by Chinese breast cancer survivors

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作者
Dan Chen
Lynette Mackenzie
Syeda Zakia Hossain
Jing-Xin Wang
Ping-Lan Jiang
Yuanxiao Wang
Lanhui Qin
Jun Zhen
Jie Jia
机构
[1] Jing’an District Central Hospital of Shanghai,Department of Rehabilitation Medicine
[2] Huashan Hospital Fudan University,Department of Rehabilitation Medicine
[3] University of Sydney,Discipline of Occupational Therapy, School of Health Sciences, Faculty of Medicine and Health
[4] University of Sydney,Discipline of Behavioural Sciences, School of Health Sciences, Faculty of Medicine and Health
[5] Zhengzhou Central Hospital of Zhengzhou University,Department of Rehabilitation Medicine
[6] Xiangya Hospital of Central South University,Department of Breast Surgery
[7] Yunnan Cancer Hospital,Department of Breast Surgery
[8] the People’s Hospital of Guangxi Zhuang Autonomous Region,Department of Rehabilitation
[9] The Fifth Affiliated Hospital of Sun Yat-Sen University,Department of Rehabilitation
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摘要
To identify cognitive function in Chinese breast cancer survivors. Research questions were: is cognitive function was associated with breast cancer and/or chemotherapy treatment and/or psychological functioning:? and did women with breast cancer experience more cognitive and psychological issues than age-matched women without cancer? Breast cancer survivors with chemotherapy (n = 106, mean age = 50.2 ± 9.5), breast cancer survivors without chemotherapy (n = 100, mean age = 50.5 ± 10.0) and matched healthy controls (n = 96, mean age = 47.9 ± 9.1) completed a battery of cognitive and psychosocial functioning. Demographic characteristics were also collected. The Perceived Cognitive Impairment score for cancer groups was significantly higher than for the healthy group (p = 0.04), but not between the cancer groups. Processing speed was significantly slower in the cancer groups than in the healthy group (both p < 0.001), but not between the cancer groups. Age, living status and education were significantly associated with the FACT-Cog (all p < 0.05). The correlations between the FACT-Cog score and BSI score were strong (r = 0.60 p < 0.01), and between the HADS anxiety and depression scales were strong (r = 0.53 and 0.50, p < 0.01) but correlations were weaker between performance based cognitive tests and measures of psychological functioning. Breast cancer groups indicated more cognitive impairment and reduced psychological functioning compared to the healthy group. However, there was no differences between the breast cancer groups. Chinese breast cancer survivors experienced excess cognitive impairment not associated with usual ageing. Assessment and intervention to address cognitive impairment should be made available to breast cancer survivors.
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