Evaluation of the Effect of β-Endorphin on IL-4 and γ-IFN Production by CD4+ Lymphocytes

被引：0
|
作者：
S. V. Gein
K. G. Gorshkova
机构：
[1] Ural Division of Russian Academy of Sciences,Institute of Ecology and Genetics of Microorganisms
来源：
Bulletin of Experimental Biology and Medicine | 2008年 / 146卷
关键词：
β-endorphin; interleukin-4; γ-interferon; CD4; cells; monocytes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
β-Endorphin stimulates phytohemagglutinin-induced production of IL-4 and does not modify the production of γ-IFN in nonfractionated leukocyte suspension. In a culture of purified CD4+ T-cells, β-endorphin does not modify the levels of IL-4 and γ-IFN, but stimulates the production of IL-4 and inhibits γ-IFN production after addition of monocytes to CD4+ lymphocytes. Stimulation of IL-4 synthesis by β-endorphin is mediated by the cycloxygenase cycle products. Hence, β-endorphin shifts T-helper polarization towards Th2 cells with subsequent predominance of the humoral form of the immune response.
引用
收藏
页码：447 / 450
页数：3
相关论文
共 50 条
  • [1] Evaluation of the Effect of β-Endorphin on IL-4 and γ-IFN Production by CD4+ Lymphocytes
    Gein, S. V.
    Gorshkova, K. G.
    [J]. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2008, 146 (04) : 447 - 450
  • [2] Effect of myelopeptides on IFN-γ and IL-4 production by peripheral blood lymphocytes
    Gein S.V.
    Gavrilova T.V.
    Chereshnev V.A.
    [J]. Doklady Biological Sciences, 2007, 413 (1) : 161 - 163
  • [3] Effect of cryopreservation on IL-4, IFNγ and IL-6 production of porcine peripheral blood lymphocytes
    Li, Xiujin
    Zhong, Zhenyu
    Liang, Shuang
    Wang, Xingxing
    Zhong, Fei
    [J]. CRYOBIOLOGY, 2009, 59 (03) : 322 - 326
  • [4] Biphasic effect of melatonin on IL-4 and IFN-γ production
    Scaletti, C
    Mavilia, C
    Maggi, E
    Romagnani, S
    Piccinni, MP
    [J]. EFIS 2000: 14TH EUROPEAN IMMUNOLOGY MEETING, 2000, : 275 - 280
  • [5] Differential effects of IFN-α on the expression of IL-4 and IL-5 in human CD4+ T cells
    Hirohata, S
    Shibuya, H
    Nagai, T
    [J]. FASEB JOURNAL, 2003, 17 (07): : C142 - C142
  • [6] SIMULTANEOUS PRODUCTION OF IL-2, IL-4, AND IFN-GAMMA BY ACTIVATED HUMAN CD4+ AND CD8+ T-CELL CLONES
    PALIARD, X
    DEWAALMALEFIJT, R
    YSSEL, H
    BLANCHARD, D
    CHRETIEN, I
    ABRAMS, J
    DEVRIES, J
    SPITS, H
    [J]. JOURNAL OF IMMUNOLOGY, 1988, 141 (03): : 849 - 855
  • [7] Differential effects of salicylates on IL-4 and IL-2 expression in human CD4+ T lymphocytes.
    Cianferoni, A
    Schroeder, JT
    Vierucci, A
    Lichtenstein, LM
    Georas, SN
    Casolaro, V
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 103 (01) : S240 - S240
  • [8] IL-4 MEDIATED INDUCTION OF IL-4 AND IL-10 PRODUCTION BY CD4+ CD45RA+ CORD-BLOOD T-CELLS IS INHIBITED BY AN IL-4 MUTANT PROTEIN
    SCHNEIDER, PV
    SOMASSE, T
    DEVRIES, JE
    YSSEL, H
    [J]. FASEB JOURNAL, 1995, 9 (04): : A1054 - A1054
  • [9] Effect of cinnamamides on atopic dermatitis through regulation of IL-4 in CD4+ cells
    Choi, Eun-Ju
    Ryu, Young Bae
    Tang, Yujiao
    Kim, Bo Ram
    Lee, Woo Song
    Debnath, Trishna
    Fan, Meiqi
    Kim, Eun-Kyung
    Lee, Hyun-Su
    [J]. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2019, 34 (01) : 613 - 619
  • [10] DX5+ CD4+ T cells modulate cytokine production by CD4+ T cells towards IL-10 via the production of IL-4
    Han, Wanda G. H.
    van der Voort, Ellen I. H.
    el Bannoudi, Hanane
    Louis-Plence, Pascale
    Huizinga, Tom W. J.
    Toes, Rene E. M.
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (10) : 2731 - 2740
12345