Neuromyelitis optica [Neuromyelitis optica]

被引：0
|
作者：
Wildemann B. [1 ]
Jarius S. [1 ]
Paul F. [2 ]
机构：
[1] Sektion Molekulare Neuroimmunologie, Neurologische Klinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400
[2] Neurocure Clinical Research Center and Experimental and Clinical Research Center, Charité-Universititätsmedizin, Campus Mitte, Berlin
来源：
Der Nervenarzt | 2013年 / 84卷 / 4期
关键词：
Aquaporin-4; antibodies; Devic syndrome; Longitudinal extensive transverse myelitis; Neuromyelitis optica; Recurrent optic neuritis;
D O I：
10.1007/s00115-012-3602-x
中图分类号：
学科分类号：
摘要：
Summary: The discovery of serum autoantibodies against the astrocytic water channel aquaporin-4 (AQP4) as a biomarker of neuromyelitis optica (NMO, Devic syndrome) has revolutionized our understanding of this rare immune-mediated clinical entity and has provided a rationale for the use of therapeutic strategies targeting the humoral effector arm of autoimmune responses. This article reviews the clinical features of NMO and highlights recent findings that have elucidated how antibodies and T cells with specificity for AQP4 may be involved in the pathophysiology of the disorder. © 2013 Springer-Verlag Berlin Heidelberg.
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页码：436 / 441
页数：5
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