Garlic oil enhances hepatic and blood antioxidants during hamster buccal pouch carcinogenesis

被引：5

作者：

Mirunalini, S ^{[1
]}

Kumaraguruparan, R ^{[1
]}

Subapriya, R ^{[1
]}

Nagini, S ^{[1
]}

机构：

[1] Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India

来源：

PHARMACEUTICAL BIOLOGY | 2004年 / 42卷 / 03期

关键词：

antioxidants; catalase; chemoprevention garlic oil; glutathione; glutathione peroxidase; glutathione S-transferase; hamster buccal pouch carcinogenesis; lipid peroxidation; superoxide dismutase;

D O I：

10.1080/13880200490514168

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

We analyzed the protective effect of garlic oil on hepatic and blood lipid peroxidation and the antioxidant status during buccal pouch carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) in male Syrian hamsters. Enhanced lipid peroxidation in the liver and blood of tumor-bearing animals was accompanied by a significant decrease in antioxidant levels. Topical application of garlic oil effectively suppressed oral carcinomas, decreased lipid peroxidation, and enhanced antioxidant levels. Our results suggest that garlic oil may exert its chemopreventive effects by modulating lipid peroxidation and enhancing antioxidant status in the liver and blood.

引用

页码：240 / 245

页数：6

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