Radical deoxygenation of hydroxyl groups via phosphites

被引：70
|
作者：
Zhang, LM
Koreeda, M [1 ]
机构：
[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Med Chem, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 41期
关键词：
D O I：
10.1021/ja0462777
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient, two-step sequence method for the deoxygenation of hydroxyl groups has been developed. The method involves the preparation of the 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol using methyl dichlorophosphite and 2-(2-iodophenyl)ethanol. Treatment of the phosphite intermediate with (n-Bu)3SnH/AIBN in refluxing benzene cleanly produces the deoxygenation product of the original alcohol. Copyright © 2004 American Chemical Society.
引用
收藏
页码：13190 / 13191
页数：2
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