A novel neutral ionic liquid-catalyzed solvent-free synthesis of 2,4,5-trisubstituted imidazoles under microwave irradiation

被引：85
|
作者：
Xia, Min [1 ]
Lu, Yue-dong [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310018, Peoples R China
来源：
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2007年 / 265卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
microwave; ionic liquid; multicomponent; solvent-free; 2,4,5-trisubstituted imidazoles;
D O I：
10.1016/j.molcata.2006.10.004
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The three-component synthesis of 2,4,5-trisubstituted imidazoles, a typical acid-catalyzed reaction, could be conducted successfully with good to excellent yields in a neutral ionic liquid, 1-methyl-3-heptyl-imidazolium tetrafluoroborate ([HeMIM]BF4), under solvent-free and microwaveassisted conditions. The combined merits of microwave irradiation and ionic liquid make the three-component condensation with safe operation, low pollution, rapid access to products and simple workup. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：205 / 208
页数：4
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