Biomarkers in Post-stroke Depression

被引:44
|
作者
Pietra Pedroso, Vinicius Sousa [1 ,2 ]
Rachid, Milene Alvarenga [1 ,2 ]
Teixeira, Antonio Lucio [1 ,2 ,3 ]
机构
[1] Univ Fed Minas Gerais, Sch Med, Interdisciplinary Lab Med Invest, Stroke Branch,Neurosci Div, Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Inst Biol Sci, Grad Program Neurosci, Belo Horizonte, MG, Brazil
[3] Univ Texas Hlth Sci Ctr Houston, Sch Med, Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX 77030 USA
关键词
Biomarkers; depression; review; stroke; neuropsychiatric; DEXAMETHASONE-SUPPRESSION TEST; SEROTONIN TRANSPORTER; SERUM-LEVELS; PROLACTIN RESPONSE; STROKE; ASSOCIATION; SYMPTOMS; MARKER; BDNF; NEUROENDOCRINE;
D O I
10.2174/1567202613666160219120114
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Depression is the most frequent neuropsychiatric complication after a stroke. Post-stroke depression has a significant impact on the outcome and prognosis of affected patients. Its diagnosis is complex and currently based only on clinical parameters. In recent years, efforts have been made to find biomarkers related to post-stroke outcomes, including complications such as depression. We carried out a systematic review of the literature looking for studies that investigated biomarkers associated with post-stroke depression (PSD) in Medline, Lilacs and PsycInfo databases. The results of 37 studies are discussed, describing the evidence for each evaluated biomarker. In conclusion, no evidence was found supporting the use of a particular biomarker for PSD. However, several changes were observed in inflammatory balance, oxidative stress, glutamatergic neurotransmission, production of neurotrophic factors, and genetic susceptibility that can be related to PSD. Research in the area of post-stroke biomarkers has the potential to provide personalized approach of stroke patients, also aiding in the diagnosis and understanding of the pathophysiology of this common neuropsychiatric complication.
引用
收藏
页码:163 / 173
页数:11
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