The polymorphic telomeres of the African trypanosome Trypanosoma brucei

被引：8
|
作者：
Rudenko, G [1 ]
机构：
[1] Univ Oxford, Dept Zool, Wellcome Trust Ctr Epidemiol Infect Dis, Oxford OX1 3FY, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2000年 / 28卷
基金：
英国惠康基金;
关键词：
antigenic variation; gene conversion; genome plasticity;
D O I：
10.1042/bst0280536
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
African trypanosomes have plastic genomes with extensive variability at the chromosome ends. The genes encoding the expressed major surface protein of the infective bloodstream form stages of Trypanosoma brucei and are located at telomeres. These telomeric expression-site transcription units are turning out to be surprisingly polymorphic in structure and sequence.
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页码：536 / 540
页数：5
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