Chemical constituents from the Colombian medicinal plant Maytenus laevis

被引:34
|
作者
Nakagawa, H
Takaishi, Y [1 ]
Fujimoto, Y
Duque, C
Garzon, C
Sato, M
Okamoto, M
Oshikawa, T
Ahmed, SU
机构
[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan
[2] Tokyo Inst Technol, Dept Chem & Mat Sci, Tokyo 1528551, Japan
[3] Univ Nacl Colombia, Dept Quim, AA-14490 Bogota, Colombia
[4] Univ Nacl Colombia, Inst Ciencias Nat, AA-14490 Bogota, Colombia
[5] Univ Tokushima, Sch Dent, Tokushima 7708504, Japan
来源
JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 11期
关键词
D O I
10.1021/np040006s
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The methanol extract of the bark of the Colombian medicinal plant Maytenus laevis gave six new compounds and 28 known compounds. The structures of the new and known compounds were elucidated on the basis of spectroscopic evidence. Several of these compounds were screened for cytokine-inducing activity on human PBMCs to investigate antitumor effects, and canophyllol (12) demonstrated the most effective induction of the cytokines.
引用
收藏
页码:1919 / 1924
页数:6
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