Human lysyl oxidase-like 2

被引：108
|
作者：
Moon, Hee-Jung [1 ]
Finney, Joel [1 ]
Ronnebaum, Trey [1 ]
Mure, Minae [1 ]
机构：
[1] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA
来源：
BIOORGANIC CHEMISTRY | 2014年 / 57卷
关键词：
Lysyl oxidase family; Lysyl oxidase like-2; Lysine tyrosylquinone (LTQ); Cell signaling; Extracellular matrix; Tumor metastasis/invasion; COPPER AMINE OXIDASE; BREAST-CANCER CELLS; EPITHELIAL-MESENCHYMAL TRANSITIONS; TUMOR PROGRESSION; QUINONE COFACTOR; POSTTRANSLATIONAL MODIFICATIONS; MOLECULAR-MECHANISMS; STROMAL FIBROBLASTS; ENZYMATIC-ACTIVITY; SECRETED LOXL2;
D O I：
10.1016/j.bioorg.2014.07.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lysyl oxidase like-2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises Cu2+- and lysine tyrosylquinone (LTQ)-dependent amine oxidases. LOXL2 is proposed to function similarly to LOX in the extracellular matrix (ECM) by promoting crosslinking of collagen and elastin. LOXL2 has also been proposed to regulate extracellular and intracellular cell signaling pathways. Dysregulation of LOXL2 has been linked to many diseases, including cancer, pro-oncogenic angiogenesis, fibrosis and heart diseases. In this review, we will give an overview of the current understandings and hypotheses regarding the molecular functions of LOXL2. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：231 / 241
页数：11
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