Revisited Mechanistic Implications of the Joullie-Ugi Three-Component Reaction

被引：36
|
作者：
Katsuyama, Akira [1 ]
Matsuda, Akira [1 ,2 ]
Ichikawa, Satoshi [1 ,2 ]
机构：
[1] Hokkaido Univ, Fac Pharmaceut Sci, Kita Ku, Kita 12,Nishi 6, Sapporo, Hokkaido 0600812, Japan
[2] Hokkaido Univ, Fac Pharmaceut Sci, Ctr Res & Educ Drug Discovery, Kita Ku, Kita 12,Nishi 6, Sapporo, Hokkaido 0600812, Japan
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 11期
关键词：
D O I：
10.1021/acs.orglett.6b00827
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The effect of the solvent on the diastereoselectivity of the Joullie-Ugi three-component reaction (JU-3CR) using an alpha-substituted five-membered cyclic imine is revisited. The cis and trans isomers were generated in toluene and HFIP, respectively. Hammett analysis of the JU-3CR suggests the presence of two reaction mechanisms.
引用
收藏
页码：2552 / 2555
页数：4
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