The Diarylquinoline R207910 Is Bactericidal against Mycobacterium leprae in Mice at Low Dose and Administered Intermittently

被引：23

作者：

Gelber, Robert ^{[1
]}

Andries, Koen ^{[2
]}

Paredes, Rose Maria D. ^{[1
]}

Andaya, Cora Evelyn S. ^{[1
]}

Burgos, Jasmin ^{[1
]}

机构：

[1] Leonard Wood Mem, Cebu, Philippines

[2] Johnson & Johnson, Tibotec BVBA, Dept Antimicrobial Res, Beerse, Belgium

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 09期

关键词：

CLINICAL-TRIAL; MINOCYCLINE; ANTIBIOTICS; PEFLOXACIN; OFLOXACIN;

D O I：

10.1128/AAC.00722-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The diarylquinoline R207910 is profoundly bactericidal in a murine model of tuberculosis. Previously, R207910 was also found to be bactericidal for Mycobacterium leprae-infected mice during lag phase. Herein we evaluate the bactericidal efficacy of R207910 (1 to 120 mg/kg of body weight) when administered five times weekly, once weekly, and once monthly during logarithmic multiplication of M. leprae organisms. All treatments were found to be bactericidal, suggesting that both low and intermittent dosing with R207910 holds promise for leprosy patients.

引用

页码：3989 / 3991

页数：3

共 18 条

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