Synthesis of new 5-N-pyrazolyl amino acids, pyrazolopyrimidines and pyrazolopyridines derivatives

被引：0

作者：

Shalaby, AM ^{[1
]}

Fathalla, OA ^{[1
]}

Kassem, EMM ^{[1
]}

Zaki, MEA ^{[1
]}

机构：

[1] Natl Res Ctr, Cairo, Egypt

来源：

ACTA CHIMICA SLOVENICA | 2000年 / 47卷 / 02期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of ketene derivatives (1a,b) on treatment with 4-amino-1-phenyl-2,3-dimethyl pyrazolin-5-one gives compounds (2a,b) which react with hydrazine to afford 1-phenyl-2,3 dimethyl-4-[3-(5-amino-4-substituted)-1H-pyrazolylamino]pyrazolin-5-one (3a,b). Compounds (3a,b) on treatment with Boc. amino acids derivatives, acetic anhydride, ethyl acetoacetate and aldehydes afforded (4a-h), (5a-h), (6-10), (11a,b), respectively. Interaction of (9) or (10) with acetohydrazide, hydrazines, and then with p-bromobenzaldehyde afforded compounds (13), (14a,b) and (15), respectively. Interaction of (3a) with thioglycollic acid afforded pyrazolopyridines derivatives (16).

引用

页码：187 / 203

页数：17

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