Prime-boost immunization strategies for infectious diseases

被引：0
|
作者：
McShane, H [1 ]
机构：
[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Med, Oxford OX3 9DU, England
来源：
CURRENT OPINION IN MOLECULAR THERAPEUTICS | 2002年 / 4卷 / 01期
基金：
英国惠康基金;
关键词：
cellular immunity; heterologous; prime-boost; recombinant viruses; vaccination;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
New vaccination strategies that induce the cellular arm of the immune response are needed for the development of effective prophylactic and therapeutic vaccines against a number of intracellular pathogens. DNA vaccines, recombinant viral vectors and recombinant proteins are all effective antigen delivery systems for inducing cellular immunity; however, when used alone, the levels of specific responses they induce are low. Prime-boost immunization strategies involve using two different vaccines, each encoding the same antigen, some weeks apart. Such strategies have been shown to enhance cellular immunity in several different animal and disease models.
引用
收藏
页码：23 / 27
页数：5
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