The utility of the hERG binding assay to assess QT prolongation and a strategy for the discovery process.

被引：0

作者：

Eddy, E ^{[1
]}

机构：

[1] Millennium Pharmaceut Inc, Drug Safety & Disposit, Cambridge, MA USA

来源：

TOXICOLOGICAL SCIENCES | 2003年 / 72卷

关键词：

D O I：

暂无

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

164

引用

页码：34 / 34

页数：1

共 9 条

[1] Acquired QT interval prolongation and HERG: implications for drug discovery and development
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[5] Use of hERG binding in lead optimization provides greater predictivity for QTc prolongation in vivo compared to manual patch hERG assay
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[J]. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2018, 93 : 148 - 148
[6] Cellular impedance assay for prediction of QT prolongation induced by hERG and non-hERG channel modulators using human stem cell derived cardiomyocytes
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[J]. TOXICOLOGY LETTERS, 2013, 221 : S231 - S232
[7] Search strategy on product innovation process: Theory and evidence from the evolution of agrochemical lead discovery process.
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[8] Utility of positive controls in assessing assay sensitivity in ICH S7B and ICH E14 guidance for evaluation of QT/QTc interval prolongation
Chiang, Alan Y.
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[J]. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2010, 62 (02) : 143 - 147
[9] ANALYTICAL PERFORMANCE AND CLINICAL UTILITY OF ITACT-HBCRAG ASSAY FOR FULLY AUTOMATED ANALYZER LUMIPULSE® L2400 WITH AUTOMATED PRETREATMENT PROCESS.
Kitamura, Yoshiyuki
Mori, Takaaki
Ohue, Chiharu
Aoyagi, Katsumi
Yagi, Shintaro
[J]. HEPATOLOGY, 2021, 74 : 428A - 428A

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