Significant downregulation of interleukin (IL)-18 gene expression and protein production in activated cord blood (CB) vs. adult peripheral blood (APB) mononuclear cells (MNC) may be secondary to posttranscriptional dysregulation: Potential mechanism for differences in CB vs. APBT cell immunity

被引：0

作者：

Jie, W ^{[1
]}

Avello, J ^{[1
]}

Cairo, S ^{[1
]}

van de Ven, C ^{[1
]}

Suri, M ^{[1
]}

Baxi, LV ^{[1
]}

Cairo, MS ^{[1
]}

机构：

[1] Columbia Univ, New York, NY 10027 USA

来源：

PEDIATRIC RESEARCH | 2003年 / 53卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

引用

页码：12A / 13A

页数：2

共 20 条

[1] Significant downregulation of interleukin (IL)-18 gene expression and protein production and IL-18 induced IFN-γ production in activated cord blood (CB) vs. adult peripheral blood (APB) mononuclear cells (MNC) may be secondary to posttranscriptional dysregulation:: Potential mechanism for differences in CB vs. APB immune reconstitution and aGVHD.
Wu, J
Ayello, J
Cairo, S
van De Ven, C
Suri, M
Baxi, LV
Cairo, MS
[J]. BLOOD, 2002, 100 (11) : 51B - 51B
[2] Significant downregulation of interleukin (IL-)-18 gene expression and protein production in constitutive and activated umbilical cord blood (CB) vs. adult peripheral blood (APB) mononuclear cells (MNC): Potential mechanism for differential alloreactivity.
Wu, J
Cairo, S
van de Ven, C
Suri, MS
Baxi, LV
Cairo, MS
[J]. BLOOD, 2001, 98 (11) : 205A - 205A
[3] Dysregulation of interleukin (IL)-18 gene expression and protein production in basal and activated cord blood (CB) vs. peripheral blood (PB) mononuclear cells and differential effects of IL-18 in CB vs. PB T and NK cell immunity
Satwani, P
Ayello, J
Simpson, L
van de Ven, C
Cairo, MS
[J]. BLOOD, 2004, 104 (11) : 727A - 727A
[4] Activated cord blood (CB) vs. adult peripheral blood (APB) mononuclear cells (MNC) produce and express significantly less IL-18 protein and mRNA respectively: Implications in the immaturity of cord blood T-cell immunity
Suri, MS
Wu, J
Cairo, S
Van de Ven, C
Cairo, MS
[J]. PEDIATRIC RESEARCH, 2002, 51 (04) : 324A - 324A
[5] Down regulation of interleukin 12 (IL-12) and interleukin 15 (IL-15) gene expression and protein production in activated cord vs adult peripheral blood (APB) mononuclear cells (MNC) but up regulation by IL-12 and IL-15 cord blood (CB) anti-tumor immune activity
Cairo, MS
Lee, SM
Suen, Y
Qian, JX
Knoppel, E
vandeVen, C
[J]. EXPERIMENTAL HEMATOLOGY, 1997, 25 (08) : 357 - 357
[6] Significant decreased expression of LPS-stimulated cord blood (CB) compared to adult peripheral blood (APB) immunoregulatory, cytokine, chemokine, signal transduction and transcription factor genes by gene expression profile oligonucleotide array: Mechanisms of differential CB vs. APB cell-mediated immunity.
Hong, J
Baxi, LM
Cheung, YK
van de Ven, C
Cairo, MS
[J]. BLOOD, 2002, 100 (11) : 246A - 246A
[7] Mechanisms of dysregulation of interleukin-12 (IL-12) gene expression in activated cord vs. adult mononuclear cells (MNC): Altered post-transcriptional regulation by labile protein synthesis.
Lee, S
Suen, Y
Cairo, MS
[J]. BLOOD, 1997, 90 (10) : 1617 - 1617
[8] Significant decrease in cord blood (CB) versus adult peripheral blood (APB) monocyte (MO)-derived dendritic cell (DC) gene and protein expression patterns and T cell functional activation: Insight into immaturity of CB cellular immunity
Jiang, H
Wade-Harris, C
Baxi, L
Cairo, MS
[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2006, 12 (02) : 52 - 53
[9] Differential gene expression and protein production during maturation process of cord blood (CB) versus adult peripheral blood (APB) monocyte (Mo) into mature dendritic cells (DC): Insight into immaturity of CB cellular immunity
Jiang, H.
Wade-Harris, C.
Lim, M.
Baxi, L.
Cairo, M. S.
[J]. EXPERIMENTAL HEMATOLOGY, 2006, 34 (09) : 44 - 45
[10] Significant decreased in cord blood (CB) versus adult peripheral blood (APB) monocyte (Mo)-derived dendritic cells (DC) gene expression patterns and T cell functional activation: Insight into immaturity of CB cellular immunity.
Jiang, H
Wade-Harris, C
Baxi, L
Cairo, MS
[J]. BLOOD, 2005, 106 (11) : 624A - 624A

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