Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens

被引：704
|
作者：
Lebeer, Sarah [1 ]
Vanderleyden, Jos [1 ,2 ]
De Keersmaecker, Sigrid C. J. [1 ]
机构：
[1] Katholieke Univ Leuven, Ctr Microbial & Plant Genet, B-3001 Louvain, Belgium
[2] Katholieke Univ Leuven, INPAC, B-3001 Louvain, Belgium
来源：
NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 03期
关键词：
INTESTINAL EPITHELIAL-CELLS; LACTOBACILLUS-RHAMNOSUS GG; TOLL-LIKE RECEPTOR-2; ESCHERICHIA-COLI STRAIN; GRAM-POSITIVE BACTERIA; LACTIC-ACID BACTERIA; NF-KAPPA-B; PROINFLAMMATORY GENE-EXPRESSION; HELICOBACTER-PYLORI; DENDRITIC CELLS;
D O I：
10.1038/nrmicro2297
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
How can probiotic bacteria transduce their health benefits to the host? Bacterial cell surface macromolecules are key factors in this beneficial microorganism-host crosstalk, as they can interact with host pattern recognition receptors (PRRs) of the gastrointestinal mucosa. In this Review, we highlight the documented signalling interactions of the surface molecules of probiotic bacteria (such as long surface appendages, polysaccharides and lipoteichoic acids) with PRRs. Research on host-probiotic interactions can benefit from well-documented host-microorganism studies that span the spectrum from pathogenicity to mutualism. Distinctions and parallels are therefore drawn with the interactions of similar molecules that are presented by gastrointestinal commensals and pathogens.
引用
收藏
页码：171 / 184
页数：14
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