Treatment of acute vivax malaria with tafenoquine

被引：112
|
作者：
Nasveld, P
Kitchener, S
机构：
[1] Australian Army Malaria Inst, Clin Field Sect, Enoggera, Qld 4051, Australia
[2] Ctr Mil & Vet Hlth, Brisbane, Qld, Australia
来源：
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2005年 / 99卷 / 01期
关键词：
malaria; Plasmodium vivax; tafenoquine; Papua New Guinea;
D O I：
10.1016/j.trstmh.2004.01.013
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Tafenoquine is an 8-aminoquiniline related to primaquine with preclinical activity against a range of malaria species. We treated two acute cases of vivax malaria with tafenoquine (800 mg over three days) atone, instead of conventional chloroquine (1500 mg over three days) and primaquine (420 mg over 14 days). In addition to the convenience of this regimen, the rapid parasite clearances observed, coupled with a good clinical response and lack of recrudescence or relapse, indicate that further investigation of tafenoquine in the treatment of vivax malaria is warranted. (C) 2004 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
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页码：2 / 5
页数：4
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