Iridium-Catalyzed Enantioselective Allylic Substitution of O-Allyl Carbamothioates

被引：29
|
作者：
Xu, Qing-Long [1 ]
Liu, Wen-Bo [1 ]
Dai, Li-Xin [1 ]
You, Shu-Li [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 13期
基金：
中国国家自然科学基金;
关键词：
S BOND FORMATION; ASYMMETRIC-SYNTHESIS; KINETIC RESOLUTION; AMINATION; ETHERIFICATION; COMPLEXES; ALCOHOLS; THIOLS; HETEROCYCLES; ALKYLATION;
D O I：
10.1021/jo1006152
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
With an [Ir(COD)Cl](2)/phosphoramidite ligand system, an allylic substitution of O-allyl carbamothioates was developed. The reaction proceeded in the favor of branched products with up to 93:7 branched-to-linear ratio, affording chiral S-allyl carbamothioates with up to 95% ee.
引用
收藏
页码：4615 / 4618
页数：4
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