The involvement of endothelial progenitor cells in tumor angiogenesis

被引:100
|
作者
Ribatti, D [1 ]
机构
[1] Univ Bari, Sch Med, Dept Human Anat & Histol, Policlin Bari, I-70124 Bari, Italy
关键词
angiogenesis; endothelial progenitor cells; tumor;
D O I
10.1111/j.1582-4934.2004.tb00319.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Endothelial progenitor cells (EPCs) have been isolated from peripheral blood CD34, VEGFR-2, or AC 133 (CD 133) antigen-positive cells, which may home to site of neovascularization and differentiate into endothelial cells in situ. Endothelial cells contribute to tumor angiogenesis, and can originate from sprouting or co-option of neighbouring pre-existing vessels. Emerging evidence indicate that bone marrow-derived circulating EPCs can contribute to tumor angiogenesis and growth of certain tumors. This review article will summarize the literature data concerning this new role played by EPCs in tumor angiogenesis.
引用
收藏
页码:294 / 300
页数:7
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