SR 141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset

被引：1
|
作者：
Simiand, J [1 ]
Keane, M [1 ]
Keane, PE [1 ]
Soubrié, P [1 ]
机构：
[1] Sanofi Rech, Neuropsychiat Res Dept, F-31036 Toulouse, France
来源：
BEHAVIOURAL PHARMACOLOGY | 1998年 / 9卷 / 02期
关键词：
cannabinoid; marmoset; SR; 141716; sweet food;
D O I：
暂无
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
SR 141716 (1 and 3 mg/kg p.o.), a selective central (CB1) cannabinoid receptor antagonist, selectively reduced feeding of a very highly palatable cane-sugar mixture in marmosets. In contrast, standard primate pellet intake was not modified at the lower dose, but was slightly increased (+29%; p<0.01) by the higher dose of SR 141716. These results are in agreement with the hypothesis that endogenous cannabinoid systems are involved in the modulation of the appetitive value of food. (C) 1998 Rapid Science Ltd.
引用
收藏
页码：179 / 181
页数：3
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