Current ante-mortem techniques for diagnosis of bovine tuberculosis

被引:92
|
作者
Bezos, Javier [1 ,2 ]
Casal, Carmen [2 ]
Romero, Beatriz [2 ]
Schroeder, Bjoern [3 ]
Hardegger, Roland [3 ]
Raeber, Alex J. [3 ]
Lopez, Lissette [4 ]
Rueda, Paloma [4 ]
Dominguez, Lucas [2 ,5 ]
机构
[1] MAEVA SERVET SL, Madrid 28749, Spain
[2] Univ Complutense, Ctr Vigilancia Sanitaria Vet VISAVET, E-28040 Madrid, Spain
[3] Prion AG, CH-8952 Zurich, Switzerland
[4] INGENASA, Madrid 28037, Spain
[5] Univ Complutense Madrid, Fac Vet, Dept Sanidad Anim, E-28040 Madrid, Spain
关键词
Tuberculosis; Cattle; Tuberculin test; Gamma-interferon assay; Serology; ENZYME-LINKED-IMMUNOSORBENT; ANTIGEN PRINT IMMUNOASSAY; IN-FIELD TRIALS; MYCOBACTERIUM-BOVIS; SKIN-TEST; GAMMA-INTERFERON; INFECTED CATTLE; RECOMBINANT PROTEINS; IMMUNE-RESPONSES; HYPERSENSITIVITY RESPONSES;
D O I
10.1016/j.rvsc.2014.04.002
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Bovine tuberculosis (TB), mainly caused by Mycobacterium bovis, is a zoonotic disease with implications for Public Health and having an economic impact due to decreased production and limitations to the trade. Bovine TB is subjected to official eradication campaigns mainly based on a test and slaughter policy using diagnostic assays based on the cell-mediated immune response as the intradermal tuberculin test and the gamma-interferon (IFN-gamma) assay. Moreover, several diagnostic assays based on the detection of specific antibodies (Abs) have been developed in the last few years with the aim of complementing the current diagnostic techniques in the near future. This review provides an overview of the current ante-mortem diagnostic tools for diagnosis of bovine TB regarding historical background, methodologies and sensitivity (Se) and specificity (Sp) obtained in previous studies under different epidemiological situations. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:S44 / S52
页数:9
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