Probiotic Escherichia coli NISSLE 1917 for inflammatory bowel disease applications

被引：3
|
作者：
Zhao, Zejing [1 ]
Xu, Shumin [1 ]
Zhang, Wangyang [1 ]
Wu, Danjun [1 ]
Yang, Gensheng [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
来源：
FOOD & FUNCTION | 2022年 / 13卷 / 11期
基金：
中国国家自然科学基金;
关键词：
INTESTINAL EPITHELIAL-CELLS; EPIDERMAL-GROWTH-FACTOR; E; COLI; SALMONELLA-TYPHIMURIUM; ULCERATIVE-COLITIS; IMMUNE-RESPONSE; F1C FIMBRIAE; PKC-ZETA; GUT; INDUCTION;
D O I：
10.1039/d2fo00226d
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Escherichia coli NISSLE 1917 (EcN) is a Gram-negative strain with many prominent probiotic properties in the treatment of intestinal diseases such as diarrhea and inflammatory bowel disease (IBD), in particular ulcerative colitis. EcN not only exhibits antagonistic effects on a variety of intestinal pathogenic bacteria, but also regulates the secretion of immune factors in vivo and enhances the ability of host immunity. In this review, the mechanisms of EcN in the remission of inflammatory bowel disease are proposed and recent advances on the functionalized EcN are compiled to provide novel therapeutic strategies for the prevention and treatment of IBD.
引用
收藏
页码：5914 / 5924
页数：11
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