The Coronary Artery Risk Development In Young Adults (CARDIA) Study

ment in Young Adults) study (1) was begun in 1985 to 1986. The study enrolled 5,115 Black and White men and women 18 to 30 years of age at 4 centers in Birmingham, Alabama, Chicago, Illinois, Minneapolis, Minnesota, and Oakland, California. Originally conceived as a study to understand the contributing factors (behavioral, environmental, and race- and sex-associated) underlying the transition from healthy young adulthood to the development The CARDIA (Coronary Artery Risk Development in Young Adults) study began in 1985 to 1986 with enrollment of 5,115 Black or White men and women ages 18 to 30 years from 4 US communities. Over 35 years, CARDIA has contributed fundamentally to our understanding of the contemporary epidemiology and life course of cardiovascular health and disease, as well as pulmonary, renal, neurological, and other manifestations of aging. CARDIA has established associa-tions between the neighborhood environment and the evolution of lifestyle behaviors with biological risk factors, sub-clinical disease, and early clinical events. CARDIA has also identified the nature and major determinants of Black-White differences in the development of cardiovascular risk. CARDIA will continue to be a unique resource for understanding determinants, mechanisms, and outcomes of cardiovascular health and disease across the life course, leveraging ongoing pan-omics work from genomics to metabolomics that will define mechanistic pathways involved in cardiometabolic aging. (J Am Coll Cardiol 2021;78:260-77) (c) 2021 the American College of Cardiology Foundation. Published by Elsevier. All rights reserved.