Pentamidine uptake in Leishmania donovani and Leishmania amazonensis promastigotes and axenic amastigotes

被引：64
|
作者：
Basselin, M
Lawrence, F
RobertGero, M
机构：
[1] Institut de Chimie des Substances Naturelles, C.N.R.S., 91198 Gif-sur-Yvette, Cedex, Avenue de la Terrasse
来源：
BIOCHEMICAL JOURNAL | 1996年 / 315卷
关键词：
D O I：
10.1042/bj3150631
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A transport system for pentamidine in Leishmania donovani and Leishmania amazonensis promastigotes and axenic amastigotes has been identified and characterized. Pentamidine is not metabolized by these parasites. Its uptake process is saturable, carrier-mediated and energy-dependent. This drug does not inhibit purine or pyrimidine uptake, whereas it inhibits uptake of several amino acids non-competitively and that of putrescine and spermidine competitively. The results suggest that pentamidine shares polyamine-carrier systems in these parasites.
引用
收藏
页码：631 / 634
页数：4
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