Phase II study of pegylated liposomal doxorubicin in patients with metastatic malignant melanoma failing standard chemotherapy treatment

被引：23
|
作者：
Vorobiof, DA
Rapoport, BL
Mahomed, R
Karime, M
机构：
[1] Sandton Oncol Ctr, ZA-2121 Johannesburg, South Africa
[2] Med Oncol Ctr Rosebank, Johannesburg, South Africa
来源：
MELANOMA RESEARCH | 2003年 / 13卷 / 02期
关键词：
Phase II; pegylated liposomal doxorubicin; advanced melanoma;
D O I：
10.1097/00008390-200304000-00015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fourteen patients with metastatic malignant melanoma that had failed to respond to standard dacarbazine-based chemotherapy treatment were entered into a phase II study of pegylated liposomal doxorubicin (Caelyx) given as a single intravenous injection at a dose of 50 mg/m(2) at 28 day intervals. No objective responses were documented. Treatment was well tolerated. We conclude that pegylated liposomal doxorubicin does not demonstrate sufficient activity in metastatic melanoma to warrant further investigation in this setting.
引用
收藏
页码：201 / 203
页数：3
相关论文
共 50 条
  • [1] A phase II, open label, monotherapy study of liposomal doxorubicin in patients with metastatic malignant melanoma
    Michael G. Smylie
    Ralph Wong
    Catalin Mihalcioiu
    Chris Lee
    Jean-Francois Pouliot
    [J]. Investigational New Drugs, 2007, 25 : 155 - 159
  • [2] A phase II, open label, monotherapy study of liposomal doxorubicin in patients with metastatic malignant melanoma
    Smylie, Michael G.
    Wong, Ralph
    Mihalcioiu, Catalin
    Lee, Chris
    Pouliot, Jean-Francois
    [J]. INVESTIGATIONAL NEW DRUGS, 2007, 25 (02) : 155 - 159
  • [3] Phase II Study of Bortezomib and Pegylated Liposomal Doxorubicin in the Treatment of Metastatic Breast Cancer
    Irvin, William J., Jr.
    Orlowski, Robert Z.
    Chiu, Wing-Keung
    Carey, Lisa A.
    Collichio, Frances A.
    Bernard, Philip S.
    Stijleman, Inge J.
    Perou, Charles
    Ivanova, Anastasia
    Dees, E. Claire
    [J]. CLINICAL BREAST CANCER, 2010, 10 (06) : 465 - 470
  • [4] Phase II study of pegylated liposomal doxorubicin in combination with gemcitabine in patients with metastatic breast cancer
    Rivera, E
    Valero, V
    Arun, B
    Royce, M
    Adinin, R
    Hoelzer, K
    Walters, R
    Wade, JL
    Pusztai, L
    Hortobagyi, GN
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (17) : 3249 - 3254
  • [5] Pegylated liposomal doxorubicin plus carboplatin in patients with metastatic breast cancer: a phase II study
    Collea, R. P.
    Kruter, F. W.
    Cantrell, J. E.
    George, T. K.
    Kruger, S.
    Favret, A. M.
    Lindquist, D. L.
    Melnyk, A. M.
    Pluenneke, R. E.
    Shao, S. H.
    Crockett, M. W.
    Asmar, L.
    O'Shaughnessy, J.
    [J]. ANNALS OF ONCOLOGY, 2012, 23 (10) : 2599 - 2605
  • [6] Weekly pegylated liposomal doxorubicin and paclitaxel in patients with metastatic breast carcinoma: A phase II study
    Leonardi, Vita
    Palmisano, Valentina
    Pepe, Alessio
    Usset, Antonella
    Manuguerra, Giovanna
    Savio, Giuseppina
    De Bella, Manuela Tamburo
    Laudani, Agata
    Alu, Massimo
    Cusimano, Maria Pia
    Scianna, Caterina
    Giresi, Armando
    Agostara, Biagio
    [J]. ONCOLOGY LETTERS, 2010, 1 (04) : 749 - 753
  • [7] Clinical phase II study of pegylated liposomal doxorubicin as second-line treatment in disseminated melanoma
    Fink, W
    Zimpfer-Rechner, C
    Thoelke, A
    Figl, R
    Kaatz, M
    Ugurel, S
    Schadendorf, D
    [J]. ONKOLOGIE, 2004, 27 (06): : 540 - 544
  • [8] A phase II study of pegylated liposomal doxorubicin for treatment of advanced hepatocellular carcinoma
    Halm, U
    Etzrodt, G
    Schiefke, I
    Schmidt, F
    Witzigmann, H
    Mössner, J
    Berr, F
    [J]. ANNALS OF ONCOLOGY, 2000, 11 (01) : 113 - 114
  • [9] Pegylated liposomal doxorubicin (PEG-LD) and paclitaxel in patients with metastatic breast carcinoma: A phase II study
    Leonardi, V
    Palmisano, V
    Pepe, A.
    Usset, A.
    Savio, G.
    Laudani, A.
    Calabria, C.
    Giresi, A.
    Carruba, G.
    Agostara, B.
    [J]. ANNALS OF ONCOLOGY, 2006, 17 : XI10 - XI10
  • [10] Pegylated liposomal doxorubicin (Peg-LD) and paclitaxel in patients with metastatic breast carcinoma: A phase II study
    Leonardi, Vita
    Palmisano, Valentina
    Pepe, Alessio
    Usset, Antonella
    Savio, Giuseppina
    Laudani, Agata
    Calabria, Caterina
    Rondello, Giacomo
    Carruba, Giuseppe
    Agostara, Biagio
    [J]. ANNALS OF ONCOLOGY, 2006, 17 : 85 - 85
12345