Synthesis and cytotoxic activity of the N-acetylglucosamine-bearing triterpenoid saponins

被引：23
|
作者：
Wang, Peng [2 ]
Wang, Jun [2 ]
Guo, TianTian [2 ]
Li, Yingxia [1 ]
机构：
[1] Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
[2] Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China
来源：
CARBOHYDRATE RESEARCH | 2010年 / 345卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Ursolic acid; Oleanolic acid; Saponin; N-Acetylglucosamine; Cytotoxic activity; ANTI-HIV ACTIVITY; OLEANOLIC ACID; URSOLIC ACID; ANTITUMOR-ACTIVITY; BETULINIC ACID; AIDS AGENTS; DERIVATIVES; GLYCOPROTEINS;
D O I：
10.1016/j.carres.2010.01.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fourteen ursolic acid and oleanolic acid saponins with N-acetyl-beta-D-glucosamine, and (1 -> 4)-linked and (1 6)-linked N-acetyl-beta-D-glucosamine oligosaccharide residues were synthesized in a convergent manner. The structures of all compounds were confirmed by (1)H NMR and (13)C NMR spectroscopy and by mass spectrometry, and their cytotoxic activities were assayed in three cancer cell lines. Only oleanolic acid-3-yl beta-D-GluNAc showed significant cytotoxicity against HL-60 and BGC-823. (C) 2010 Published by Elsevier Ltd.
引用
收藏
页码：607 / 620
页数：14
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