Cell transcriptomic atlas of the non-human primate Macaca fascicularis

被引：103

作者：

Han, Lei ^{[1
,2
,3
]}

Wei, Xiaoyu ^{[1
,4
]}

Liu, Chuanyu ^{[1
,2
,3
]}

Volpe, Giacomo ^{[5
]}

Zhuang, Zhenkun ^{[1
,6
]}

Zou, Xuanxuan ^{[1
,4
]}

Wang, Zhifeng ^{[1
,2
]}

Pan, Taotao ^{[1
,2
]}

Yuan, Yue ^{[1
,4
]}

Zhang, Xiao ^{[7
]}

Fan, Peng ^{[7
]}

Guo, Pengcheng ^{[7
]}

Lai, Yiwei ^{[8
]}

Lei, Ying ^{[1
,2
,3
]}

Liu, Xingyuan ^{[7
]}

Yu, Feng ^{[8
]}

Shangguan, Shuncheng ^{[9
,10
]}

Lai, Guangyao ^{[9
,10
]}

Deng, Qiuting ^{[1
,4
]}

Liu, Ya ^{[1
,2
]}

Wu, Liang ^{[1
,2
,4
]}

Shi, Quan ^{[1
,11
]}

Yu, Hao ^{[1
]}

Huang, Yunting ^{[1
,12
]}

Cheng, Mengnan ^{[1
,4
]}

Xu, Jiangshan ^{[1
,4
]}

Liu, Yang ^{[1
,4
]}

Wang, Mingyue ^{[1
]}

Wang, Chunqing ^{[1
,4
]}

Zhang, Yuanhang ^{[1
,4
]}

Xie, Duo ^{[1
,4
]}

Yang, Yunzhi ^{[13
,14
]}

Yu, Yeya ^{[13
,14
]}

Zheng, Huiwen ^{[13
,14
]}

Wei, Yanrong ^{[13
,14
]}

Huang, Fubaoqian ^{[1
,6
]}

Lei, Junjie ^{[1
,4
]}

Huang, Waidong ^{[1
,4
]}

Zhu, Zhiyong ^{[1
,4
]}

Lu, Haorong ^{[1
,12
]}

Wang, Bo ^{[1
,12
]}

Wei, Xiaofeng ^{[1
,12
]}

Chen, Fengzhen ^{[1
,12
]}

Yang, Tao ^{[1
,12
]}

Du, Wensi ^{[1
,12
]}

Chen, Jing ^{[1
,12
]}

Xu, Shibo ^{[15
]}

An, Juan ^{[8
,16
]}

Ward, Carl ^{[8
]}

Wang, Zongren ^{[17
]}

机构：

[1] BGI Shenzhen, Shenzhen, Peoples R China

[2] BGI Beijing, Beijing, Peoples R China

[3] Shenzhen Bay Lab, Shenzhen, Peoples R China

[4] Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China

[5] IRCCS Ist Tumori Giovanni Paolo II, Hematol & Cell Therapy Unit, Bari, Italy

[6] South China Univ Technol, Sch Biol & Biol Engn, Guangzhou, Peoples R China

[7] Jilin Univ, Coll Vet Med, Inst Zoonosis,Minist Educ, State Key Lab Zoonot Dis,Key Lab Zoonosis Res, Changchun, Peoples R China

[8] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Integrat Biol, Guangzhou, Peoples R China

[9] Guangzhou Inst Biomed & Hlth, Joint Sch Life Sci, Guangzhou, Peoples R China

[10] Guangzhou Med Univ, Guangzhou, Peoples R China

[11] Univ Copenhagen, Dept Biol, Copenhagen, Denmark

[12] BGI Shenzhen, China Natl GeneBank, Shenzhen, Peoples R China

[13] Zhengzhou Univ, BGI Coll, Zhengzhou, Peoples R China

[14] Zhengzhou Univ, Henan Inst Med & Pharmaceut Sci, Zhengzhou, Peoples R China

[15] Nanjing Med Univ, Sch Pharm, Inst Stem Cells & Neural Regenerat, State Key Lab Reprod Med, Nanjing, Peoples R China

[16] Univ Sci & Technol China, Hefei, Peoples R China

[17] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Urol, Guangzhou, Peoples R China

[18] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou, Peoples R China

[19] Huazhen Biosci, Guangzhou, Peoples R China

[20] Tianjin Med Univ Gen Hosp, Dept Orthoped, Tianjin, Peoples R China

[21] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab Metab & Cell Fate, Guangzhou, Peoples R China

[22] Hannover Med Sch, Inst Expt Hematol, Hannover, Germany

[23] Harvard Med Sch, Div Hematol Oncol, Boston, MA 02115 USA

[24] Spanish Natl Ctr Cardiovasc Res CNIC, Madrid, Spain

[25] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, State Key Lab Resp Dis, Guangzhou, Peoples R China

[26] Jinan Univ, Guangzhou, Peoples R China

[27] Hubei Topgene Biotechnol Co Ltd, Wuhan, Peoples R China

[28] Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Neurosci, State Key Lab Neurosci,CAS Key Lab Primate Neurob, Shanghai, Peoples R China

[29] Univ Cambridge, Cambridge Inst Med Res, Dept Med, Cambridge, England

[30] A STAR Inst Mol & Cell Biol, Singapore, Singapore

[31] Pompeu Fabra Univ UPF, Dept Expt & Hlth Sci, ICREA, Barcelona, Spain

[32] CIBERNED, Barcelona, Spain

[33] KTH Royal Inst Technol, Dept Prot Sci, Sci Life Lab, Stockholm, Sweden

[34] Karolinska Inst, Dept Neurosci, Stockholm, Sweden

[35] Kunming Univ Sci & Technol, Inst Primate Translat Med, State Key Lab Primate Biomed Res, Kunming, Yunnan, Peoples R China

[36] James D Watson Inst Genome Sci, Hangzhou, Peoples R China

[37] Guangdong Prov Key Lab Genome Read & Write, Shenzhen, Peoples R China

[38] Chinese Acad Sci, Inst Stem Cells & Regenerat, Beijing, Peoples R China

来源：

NATURE | 2022年 / 604卷 / 7907期

基金：

日本学术振兴会; 中国国家自然科学基金;

关键词：

STEM/PROGENITOR CELLS; ADIPOSE-TISSUE; STEM-CELLS; SINGLE; DISEASE; PATHOGENESIS; COVID-19; LGR5; RICH;

D O I：

10.1038/s41586-022-04587-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell-cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs. A large-scale single-cell transcriptomic atlas of the non-human primate Macaca fascicularis encompasses over 1 million cells from 45 adult tissues.

引用

页码：723 / +

页数：16

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