共 1 条
fpr, a Deficient Xer Recombination Site from a Salmonella Plasmid, Fails To Confer Stability by Dimer Resolution: Comparative Studies with the pJHCMW1 mwr Site
被引:7
|作者:
Tran, Tung
[1
,2
]
Sherratt, David J.
[2
]
Tolmasky, Marcelo E.
[1
,2
]
机构:
[1] Calif State Univ Fullerton, Coll Nat Sci & Math, Dept Biol Sci, Ctr Appl Biotechnol Studies, Fullerton, CA 92834 USA
[2] Univ Oxford, Dept Biochem, Div Mol Genet, Oxford OX1 3QU, England
基金:
美国国家卫生研究院;
英国惠康基金;
关键词:
KLEBSIELLA-PNEUMONIAE;
NUCLEOTIDE-SEQUENCE;
CER;
RESISTANCE;
INSTABILITY;
MUTAGENESIS;
AMPICILLIN;
REQUIRES;
SYSTEM;
TN1331;
D O I:
10.1128/JB.01082-09
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Salmonella plasmid pFPTB1 includes a Tn3-like transposon and a Xer recombination site, fpr, which mediates site-specific recombination at efficiencies lower than those required for stabilizing a plasmid by dimer resolution. Mutagenesis and comparative studies with mwr, a site closely related to fpr, indicate that there is an interdependence of the sequences in the XerC binding region and the central region in Xer site-specific recombination sites.
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页码:883 / 887
页数:5
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