Determination of Chondroitin Sulfate Content in Raw Materials and Dietary Supplements by High-Performance Liquid Chromatography with IN Detection After Enzymatic Hydrolysis: Single-Laboratory Validation First Action 2015.11

被引:2
|
作者
Brunelle, Sharon L. [1 ]
机构
[1] Brunelle Biotech Consulting, 14104 194th Ave NE, Woodinville, WA 98077 USA
基金
美国国家卫生研究院;
关键词
D O I
10.5740/jaoacint.15-0220
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A previously validated methbd for determination of chondroitin sulfate in raw materials and dietary supplements was submitted to the AOAC Expert Review Panel (ERP) for Stakeholder Panel on Dietary Supplements Set 1 Ingredients (Anthocyanins, Chondroitin, and PDE5 Inhibitors for consideration of First Action Official Methods(SM) status. The ERP evaluated the single-laboratory validation results against AOAC Standard Method Performance Requirements 2014.009. With recoveries of 100.8-101.6% in raw materials and 105.4-105.8% in finished products and precision of 0.25-1.8% RSDr within-day and 1.6-4.72% RSDr overall, the ERP adopted the method for First Action Official Methods status and provided recommendations for achieving Final Action status.
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页码:53 / 54
页数:2
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