On-line infrared spectroscopy for bioprocess monitoring

被引：99

作者：

Landgrebe, Daniel ^{[1
]}

Haake, Claas ^{[1
]}

Hoepfner, Tim ^{[1
]}

Beutel, Sascha ^{[1
]}

Hitzmann, Bernd ^{[1
]}

Scheper, Thomas ^{[1
]}

Rhiel, Martin ^{[2
]}

Reardon, Kenneth F. ^{[3
]}

机构：

[1] Leibniz Univ Hannover, Inst Tech Chem, D-30167 Hannover, Germany

[2] Novartis Biol, Proc Sci & Prod, CH-4002 Basel, Switzerland

[3] Colorado State Univ, Dept Chem & Biol Engn, Ft Collins, CO 80523 USA

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2010年 / 88卷 / 01期

关键词：

Infrared spectroscopy; Bioprocess; On-line measurement; On-line monitoring; Sensor; ANTIBODY-PRODUCTION; INTERVAL SELECTION; GENETIC-ALGORITHM; NEURAL-NETWORKS; CELL-DENSITY; AT-LINE; FERMENTATION; BIOMASS; NIR; GLUCOSE;

D O I：

10.1007/s00253-010-2743-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

One of the major aims of bioprocess engineering is the real-time monitoring of important process variables. This is the basis of precise process control and is essential for high productivity as well as the exact documentation of the overall production process. Infrared spectroscopy is a powerful analytical technique to analyze a wide variety of organic compounds. Thus, infrared sensors are ideal instruments for bioprocess monitoring. The sensors are non-invasive, have no time delay due to sensor response times, and have no influence on the bioprocess itself. No sampling is necessary, and several components can be analyzed simultaneously. In general, the direct monitoring of substrates, products, metabolites, as well as the biomass itself is possible. In this review article, insights are provided into the different applications of infrared spectroscopy for bioprocess monitoring and the complex data interpretation. Different analytical techniques are presented as well as example applications in different areas.

引用

页码：11 / 22

页数：12

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