Immunotherapy for Brain Tumors

被引：101
|
作者：
Sampson, John H. [2 ]
Maus, Marcela V. [3 ,4 ]
June, Carl H. [1 ]
机构：
[1] Univ Penn, 3400 Civ Ctr Blvd,Bldg 421, Philadelphia, PA 19104 USA
[2] Duke Univ, Durham, NC USA
[3] Massachusetts Gen Hosp, Boston, MA 02114 USA
[4] Harvard Med Sch, Boston, MA USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2017年 / 35卷 / 21期
关键词：
CHIMERIC-ANTIGEN-RECEPTOR; DENDRITIC CELL VACCINATION; T-CELLS; RECURRENT GLIOBLASTOMA; OPEN-LABEL; B-CELL; CANCER; BLOCKADE; SURVIVAL; REGRESSION;
D O I：
10.1200/JCO.2017.72.8089
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Glioblastoma (GBM) is the most lethal form of brain tumor and remains a large, unmet medical need. This review focuses on recent advances in the neurosciences that converge with the broader field of immuno-oncology. Recent findings in neuroanatomy provide a basis for new approaches of cellular therapies for tumors that involve the CNS. The ultimate success of immunotherapy in the CNS will require improved imaging technologies and methods for analysis of the tumor microenvironment in patients with GBM. It is likely that combinatorial approaches with targeted immunotherapies will be required to exploit the vulnerabilities of GBM and other brain tumors. (C) 2017 by American Society of Clinical Oncology
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收藏
页码：2450 / +
页数：9
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