Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis

被引：87

作者：

Chen, Jun ^{[1
]}

Zhang, Xixi ^{[1
]}

Millican, Reid ^{[2
]}

Sherwood, Jennifer ^{[2
]}

Martin, Sean ^{[1
]}

Jo, Hanjoong ^{[4
,5
,6
]}

Yoon, Young-sup ^{[6
,7
]}

Brott, Brigitta C. ^{[3
]}

Jun, Ho-Wook ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Biomed Engn, Birmingham, AL 35294 USA

[2] Endomimetics LLC, Birmingham, AL USA

[3] Univ Alabama Birmingham, Div Cardiovasc Dis, Dept Med, Birmingham, AL USA

[4] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA

[5] Emory Univ, Atlanta, GA 30322 USA

[6] Emory Univ, Dept Med, Div Cardiol, Atlanta, GA 30322 USA

[7] Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Seoul, South Korea

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2021年 / 170卷

基金：

新加坡国家研究基金会; 美国国家卫生研究院;

关键词：

Atherosclerosis; Nanomaterials; Therapeutic delivery system; Imaging contrast agents; Theranostic agents; Clinical use; HIGH-DENSITY-LIPOPROTEIN; SUPERPARAMAGNETIC IRON-OXIDE; PLASMONIC PHOTOTHERMAL THERAPY; HYALURONIC-ACID NANOPARTICLES; MEDIATED TARGETED DELIVERY; HDL MIMETIC CER-001; IN-STENT RESTENOSIS; FOAM CELL-FORMATION; SMOOTH-MUSCLE-CELL; GRAPHENE OXIDE;

D O I：

10.1016/j.addr.2021.01.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in arteries, leading to narrowing and thrombosis. It affects the heart, brain, and peripheral vessels and is the leading cause of mortality in the United States. Researchers have strived to design nanomaterials of various functions, ranging from noninvasive imaging contrast agents, targeted therapeutic delivery systems to multifunctional nanoagents able to target, diagnose, and treat atherosclerosis. Therefore, this review aims to summarize recent progress (2017 now) in the development of nanomaterials and their applications to improve atherosclerosis diagnosis and therapy during the preclinical and clinical stages of the disease. (c) 2021 Elsevier B.V. All rights reserved.

引用

页码：142 / 199

页数：58

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