The Lard Works in Mysterious Ways: Ceramides in Nutrition-Linked Chronic Disease

被引：14

作者：

Nicholson, Rebekah J. ^{[1
,2
]}

Norris, Marie K. ^{[1
,2
]}

Poss, Annelise M. ^{[1
,2
]}

Holland, William L. ^{[1
,2
]}

Summers, Scott A. ^{[1
,2
]}

机构：

[1] Univ Utah, Dept Nutr & Integrat Physiol, Coll Hlth, Salt Lake City, UT 84112 USA

[2] Univ Utah, Diabet & Metab Res Ctr, Coll Med, Salt Lake City, UT 84112 USA

来源：

ANNUAL REVIEW OF NUTRITION | 2022年 / 42卷

基金：

美国国家卫生研究院;

关键词：

CORONARY-ARTERY-DISEASE; INSULIN SENSITIVITY; GASTRIC BYPASS; PLASMA CERAMIDES; SERINE PALMITOYLTRANSFERASE; SPHINGOLIPID METABOLISM; CARDIOVASCULAR RISK; HEPATIC STEATOSIS; SALVAGE PATHWAY; SKELETAL-MUSCLE;

D O I：

10.1146/annurev-nutr-062220-112920

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Diet influences onset, progression, and severity of several chronic diseases, including heart failure, diabetes, steatohepatitis, and a subset of cancers. The prevalence and clinical burden of these obesity-linked diseases has risen over the past two decades. These metabolic disorders are driven by ectopic lipid deposition in tissues not suited for fat storage, leading to lipotoxic disruption of cell function and survival. Sphingolipids such as ceramides are among the most deleterious and bioactive metabolites that accrue, as they participate in selective insulin resistance, dyslipidemia, oxidative stress and apoptosis. This review discusses our current understanding of biochemical pathways controlling ceramide synthesis, production and action; influences of diet on ceramide levels; application of circulating ceramides as clinical biomarkers of metabolic disease; and molecular mechanisms linking ceramides to altered metabolism and survival of cells. Development of nutritional or pharmacological strategies to lower ceramides could have therapeutic value in a wide range of prevalent diseases.

引用

页码：115 / 144

页数：30