Synthesis of Aculeatins A and B via Iterative Hydrolytic Kinetic Resolution

被引：12
|
作者：
Harbindu, Anand [1 ]
Kumar, Pradeep [1 ]
机构：
[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India
来源：
SYNTHESIS-STUTTGART | 2010年 / 09期
关键词：
hydrolytic kinetic resolution; Linchpin coupling; epoxide; spirocyclization; aculeatins; MULTICOMPONENT LINCHPIN COUPLINGS; HYPERVALENT IODINE OXIDATION; EFFICIENT TOTAL-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; TERMINAL EPOXIDES; AMOMUM-ACULEATUM; CONCISE SYNTHESIS; DERIVATIVES;
D O I：
10.1055/s-0029-1218687
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and concise approach for the synthesis of aculeatins A and B starting from (+/-)-epichlorohydrin is described. The synthetic strategy features Jacobsen's hydrolytic kinetic resolution and a Linchpin coupling as key steps.
引用
收藏
页码：1479 / 1484
页数：6
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